Salem Hawley may be a free man after the American Revolution, but his troubles are plenty. A good friend seeks his help, turning Salem's attention to the graves being emptied and the deceased experimented upon and studied by medical students and physicians. It goes ignored, yet Salem is determined to do something, anything. If only he knew about the rituals being performed, the Old Ones being worshiped, right under his nose. If only he knew that New York City is on the cusp of ruin.
Leo Cartwright's retirement plan doesn't go exactly to plan - not when he meets Christopher Tate after his very last show. Christopher has a secret to share, one that he entrusts with his favourite comedian. When Christopher ends up dead soon thereafter, what's Leo to do but act on the information he's been given, even if it's completely insane? Setting out to find the mysterious town named Elswich, Leo can't deny there's something off about the entire thing. For one thing, the community of the town doesn't seem normal.
Estranged Ana and Rachel Logan take a much-needed vacation to Thailand - perhaps their sisterhood could even be mended along the way. After an intense party session their group mysteriously wake up on a boat, the ocean carrying them toward a seemingly deserted island. As nightfall hangs over them, tempers rise, survival instincts kick in, and something evil lurks in the wilderness. Who will perish to the unknown?